1506 CE
A year defined by the death of Christopher Columbus, the death of Philip the Handsome of Castile, the laying of the cornerstone for the new St. Peter's Basilica, and the Lisbon massacre of converted Jews.
Geopolitics & Diplomacy
- Philip the Handsome died suddenly in September in Burgos, leaving his wife Joanna grief-stricken and enabling Ferdinand of Aragon to reassert his regency over Castile.
- Pope Julius II laid the cornerstone for the new St. Peter's Basilica in Rome on April 18, beginning a massive construction project that would take over a century to complete.
- Ferdinand of Aragon moved to secure his position as regent of Castile following Philip's death, sidelining the increasingly unstable Queen Joanna from active governance.
Conflict & Security
- The Lisbon massacre of April saw a mob attack and kill thousands of New Christians (converted Jews) over three days, with the violence triggered by religious tensions and economic grievances.
- Portuguese naval forces under Tristao da Cunha attacked cities along the East African coast, reinforcing Portuguese military dominance over the Swahili trading network.
- Tensions between the sons of Ottoman Sultan Bayezid II escalated, with Prince Selim building military support among the Janissaries for an eventual bid for the throne.
Economy & Finance
- The death of Philip the Handsome disrupted commercial confidence in Castile, as the political uncertainty of the succession affected trade and financial markets.
- The construction of the new St. Peter's Basilica in Rome required massive financial resources, prompting the papacy to expand its fundraising activities including the sale of indulgences.
- The Atlantic slave trade grew as Portuguese merchants transported increasing numbers of enslaved Africans to supply labor demands on plantations and in colonial territories.
Technology & Infrastructure
- The foundation of the new St. Peter's Basilica was laid according to designs by Donato Bramante, featuring a monumental centralized plan inspired by classical Roman architecture.
Science & Discovery
- Tristao da Cunha's fleet explored islands in the South Atlantic during its voyage to India, with the remote archipelago that bears his name being sighted for the first time by Europeans.
- Nicolaus Copernicus, having returned to Poland, served as a canon at the cathedral in Frombork while continuing his astronomical observations and theoretical work.
Health & Medicine
- Christopher Columbus died on May 20 in Valladolid, Spain, suffering from reactive arthritis and other ailments contracted during his years of transatlantic voyaging.
Climate & Environment
- Atmospheric carbon dioxide concentration was approximately 273 parts per million, as later confirmed by ice core analysis.
- The South Atlantic islands sighted by Tristao da Cunha represented some of the most remote and ecologically isolated landmasses on Earth.
Culture & Society
- Christopher Columbus died on May 20 in Valladolid, largely forgotten by the Spanish court, still believing he had reached the outskirts of Asia rather than a new continent.
- The foundation of the new St. Peter's Basilica marked the beginning of one of the most ambitious architectural and artistic projects in Western history.
- Andrea Mantegna, the renowned Italian Renaissance painter known for his mastery of perspective, died in September in Mantua.
- The Lisbon massacre exposed deep social and religious tensions in Portugal, with violence against New Christians revealing the fragility of coexistence between communities.
- The estimated global population was approximately 485 million people, with the largest concentrations in China, the Indian subcontinent, and Europe.